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- Tth coa synthesis in 2021
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Tth coa synthesis in 2021
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What is the biosynthetic pathway for CoA synthesis?
Details of the biosynthetic pathway of CoA synthesis from pantothenic acid. Pantothenate (vitamin B 5) is phosphorylated to 4′-phosphopantothenate by the enzyme pantothenate kinase (PanK; CoaA; CoaX). This is the committed step in CoA biosynthesis and requires ATP.
Where does the NADPH for fatty acid synthesis come from?
Fatty acid synthesis utilizes two molecules of NADPH for each molecule of acetate incorporated into long-chain fatty acids. In liver, glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase (Fig. 1) probably furnish about half of the NADPH used in fatty acid synthesis, with the other half coming from malic enzyme.
Where does acetyl-CoA go in the synthesis of citrate?
Under these conditions, acetyl-CoA is transported out of the mitochondrion to the cytosol where it can be used in fatty acid synthesis. This is accomplished using the tricarboxylate transport system in the inner mitochondrial membrane which pumps citrate out Acetyl-CoA, of course, is used in the synthesis of citrate when combined with oxaloacetate.
Where does the synthesis of HMG-CoA take place?
The synthesis of HMG-CoA takes place in the following steps: 2 acetyl CoA molecules combine to form acetoacetyl- CoA, in the presence of enzyme thiolase. The 3rd molecule of acetyl CoA is added to form 3-Hydroxy-3-Methylglutaryl CoA (HMG-CoA). This takes place in the presence of enzyme HMG-CoA synthase. It is a cytosolic enzyme.
Last Update: Oct 2021