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Remedial index- Pharmacology Box This approximately 400-word essay describes the equation for curative index together with easily understandable descriptions for how the ED50 and TD50 are determined from quantal dose-response relationships. Several examples of drugs with A narrow therapeutic power are provided At the end.
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1 drug concentration at the site of action cannot be routinely measured, but the desired or adverse effects may correlate better with plasma or blood concentrations than they.
The discovery of penicillin and the initial recognition of its therapeutic potential occurred in the united kingdom, but, due to world war ii, the united states played the major role in developing large-scale production of the drug, thus making a life-saving substance in limited supply into a widely available medicine.
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Therapeutic classification of drugs drugs are grouped into different groups according to their chemical characteristics, anatomical structure and how they are used to treat specific disease.
By convention, the doses that produce the therapeutic effect and the toxic consequence in fifty pct of the universe are employed; these are known every bit the ed50 and td50, respectively.
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The therapeutic index of drugs is the ratio between the amount of do drugs needed to killing 50% of the cells of the experimental animals and the dose requisite for 50% of the cells to respond.
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The therapeutic back breaker of a do drugs is the quantity needed to.
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The therapeutic index is the ratio of the highest back breaker of the do drugs that is non toxic to the patient to the amount of do drugs required to green goods the desired effect.
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This data is used to individualise dosage indeed that drug concentrations can be kept up within a object range.
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What does it mean to have a large therapeutic ratio?
A large therapeutic ratio means that a person would have to take many times the effective dose in order to experience harmful effects. Drugs with a smaller therapeutic index may still be used, but are often only taken under a doctor's supervision.
How is the therapeutic ratio used in animal studies?
When animal studies are used to calculate the therapeutic index, the process is slightly different. In this case, the dose that causes 50 percent of the animals in the study to die, or the LD50, is used for the equation. The therapeutic ratio is then found by dividing the LD50 by the ED50.
What do you need to know about the therapeutic index?
It can, therefore, be useful to know the ratio of the average dosage of a drug needed to have an intended therapeutic effect versus the average dosage that can cause harm. This ratio is called the therapeutic index, or the therapeutic ratio. A patient can use the therapeutic index to learn about any drawbacks associated with a given medication.
Last Update: Oct 2021
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